August 18th, 2015 |

X-linked Adrenoleukodystrophy Database

X-linked adrenoleukodystrophy (X-ALD) is the most frequent inherited disorder of the central nervous system white matter with a minimum incidence of 1 in 17.000 newborns. It is a progressive, systemic metabolic disease that affects myelin, spinal cord, peripheral nerves, adrenal cortex and testis. The disease is caused by mutations in the ABCD1 gene. For a comprehensive summary, please visit the Facts on X-ALD page.

The X-ALD database was initiated July 1999 by Hugo W. Moser, M.D. and Stephan Kemp, Ph.D.
The primary aims of the database are:

  1. Catalogue and facilitate the analysis of X-ALD mutations,
  2. Provide background information on X-ALD,
  3. Provide links to X-ALD patient organizations, and
  4. Help with contacting and finding (local) X-ALD health care professionals.


NEWS: ALD Connect launches its Patient Portal so the X-ALD community can take an active role in developing greater understanding and new therapies in the fight against X-ALD. You can now participate in a research study to create a global database of X-ALD patients, their symptoms, and their priorities. Please visit the ALD Connect Patient Portal page for more information.

New or updated pages:


The X-ALD database is a collaboration between the Peroxisomal Diseases Laboratory at the Kennedy Krieger Institute, Baltimore MD, USA and the Laboratory Genetic Metabolic Diseases at the Academic Medical Center / Emma Children’s Hospital, Amsterdam, the Netherlands.

We thank the Netherlands X-ALD Patient Organization for financial support.

Academic Medical Center

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