ALDP orthologs

November 7th, 2016 |

Alignment of ALDP proteins in different species

                  .         .         .         .              .         .
HUMAN             MPVLSRP-RPWRGNTLKRTAVLLALAAYGAHKVYP-----LVRQCLAPARGLQAPAG--E 52
GORILLA           MPVLSRP-RPWRGNTLKRTAVLLALAAYGAHKVYP-----LVRQCLAPARGLQAPAG--E 52
CHIMPANZEE        MPVLSRP-RPWRGNTLKRTAVLLALAAYGAHKVYP-----LVRQCLAPARGLQAPAG--E 52
MACAQUE           MPVLSRP-RPWRGSTLKRTAVLLALAAYGVHKVYP-----LVRQCLAPARGSQAPAR--E 52
COW               MTVLSTP-RASRVTTLKRTAVVLALVAYGAHKLYP-----LVRQCLAPARGPQAPAVEGE 54
DOG               MPVLSTP-RSSRVTTLKRTALVLALTAYGAHKIYP-----LVRHYLAATRGPQVPAG--E 52
MOUSE             MPVLSTP-RPSRVTTLKRTAVVLALTAYGVHKIYP-----LVRQCLTPARGPQVPAG--E 52
RAT               MPVLSTPSRPSRVTTLKRTAVVLALTAYGVHKIYP-----LVRQCLTPARGPQVPAG--E 53
KANGAROO_RAT      MPVLSTP-RPSRATTLKRTAMVLALTAYGVHKIYP-----LVRQCLALARGPPVPAG--E 52
ZEBRAFISH         MSVYSKL-PSQLKKPLVKKAVVLLIALYGVKKLSPYFFGKLKGRTSKQVKGADPLTSNGE 59
                  *.* *    .   ..* :.*::* :. **.:*: *     *  :    .:*    :   *
                            .         .         .         .         . 
HUMAN             PTQEASG---VAAAKAGMNRVFLQRLLWLLRLLFPRVLCRETGLLALHSAALVSRTFLSV 109
GORILLA           PTQEASG---VAAAKAGMNRVFLQRLLWLLRLLFPRVLCRETGLLALHSAALVSRTFLSV 109
CHIMPANZEE        PTQEASG---VAAAKAGMNRVFLQRLLWLLRLLFPRVLCRETGLLALHSAALVSRTFLSV 109
MACAQUE           PTQESSG---AAAAKAGMNRVFLQRLMWLLRLLFPRVLCRETGLLALHSAALVSRTFLSV 109
COW               PTPDVSGAPVASAGKAGVNQVFLQRLLWLLRLLFPRILCRETGLLALHSAALVSRTFLSV 114
DOG               STQEVSG---ATAAKASVNRVFLQRLLGLLRLLFPRTLCRETGLLALHSASLVSRTFLSV 109
MOUSE             PTQEASG---ATATKAGMNRVFLQRLLALLRLLFPRVLCRETGLLALHSAALVSRTFLSV 109
RAT               STQEASG---ATTAKAGMNRVFLQRLLVLLRLLFPGVLCRETGLLALHSAALVSRTFLSV 110
KANGAROO_RAT      PTQEASG---TTAAKTGMNRVFLRRLLVLLRLLFPRILCRESGLLALHSAALVSRTFLSV 109
ZEBRAFISH         PLVEAAR---KRKRSPAVNREFFDRLIRLLKILFPRLFCKELGLLGFHSLALISRTFLSI 116
                  .  : :        ...:*: *: **: **::***  :*:* ***.:** :*:******:
                  .         .         .         .         .         .
HUMAN             YVARLDGRLARCIVRKDPRAFGWQLLQWLLIALPATFVNSAIRYLEGQLALSFRSRLVAH 169
GORILLA           YVARLDGRLARCIVRKDPRAFGWQLLQWLLIALPATFVNSAIRYLEGQLALSFRSRLVAH 169
CHIMPANZEE        YVARLDGRLARCIVRKDPRAFGWQLLQWLLIALPATFVNSAIRYLEGQLALSFRSRLVAH 169
MACAQUE           YVARLDGRLARCIVRKDPRAFGWQLLQWLLIALPATFVNSAIRYLEGQLALSFRSRLVAH 169
COW               YVARLDGRLARCIVRKDPQAFSWQLVQWLLIALPATFINSAIRYLEGQLALAFRSRLVAH 174
DOG               YVARLDGRLARCIVRKDPRAFGWQLLQWLLIALPATFINSAIRYLEGQLALSFRSRLVAH 169
MOUSE             YVARLDGRLARCIVRKDPRAFSWQLLQWLLIALPATFINSAIRYLEGQLALSFRSRLVAH 169
RAT               YVARLDGRLARCIVRKDPRAFSWQLLQWLLIALPATFINSAIRYLEGQLALSFRSRLVAH 170
KANGAROO_RAT      YVARLDGRLARCIVRKDPRAFSWQLLQWLLIALPATFINSAIRYLEGQLALAFRSRLVDH 169
ZEBRAFISH         YVANLDGQIVKTIVKKDPRAFVVELTKWLLIAIPATFVNSAIRYLEGQLTLAFRTRLVTH 176
                  ***.***::.: **:***:**  :* :*****:****:***********:*:**:*** *
                  .         .         .         .         .         .
HUMAN             AYRLYFSQQTYYRVSNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTL 229
GORILLA           AYRLYFSQQTYYRVSNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTL 229
CHIMPANZEE        AYRLYFSQQTYYRVSNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTL 229
MACAQUE           AYRLYFSQQTYYRVSNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTL 229
COW               AYSLYFSQQTYYRVSNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTTYTL 234
DOG               AYSLYFSQQTYYRVSNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTAYTL 229
MOUSE             AYGLYFSQQTYYRVSNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTL 229
RAT               AYGLYFSQQTYYRVSNMDGRLRNPDQSLTEDMVAFAASVAHLYSNLTKPLLDVAVTSYTL 230
KANGAROO_RAT      AYSLYFTQQTYYRVSNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTL 229
ZEBRAFISH         AYMLYFSDQTYYRVSNMDGRLANPDQSLTEDVVMFAASVAHLYSNLTKPILDVVVTCYTL 236
                  ** ***::************* *********:* ***************:***.** ***
                  .         .         .         .         .         .
HUMAN             LRAARSRGAGTAWPSAIAGLVVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVAN 289
GORILLA           LRAARSRGAGTAWPSAIAGLVVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVAN 289
CHIMPANZEE        LRAARSRGAGTAWPSAIAGLVVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVAN 289
MACAQUE           LQAARSRGAGTAWPSAIAGLVVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVAN 289
COW               VRAARSRGAGTAWPSAIAGLVVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVAN 294
DOG               LRAARSRGAGTAWPSAIAGLVVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVAN 289
MOUSE             LRAARSRGAGTAWPSAIAGLVVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVAN 289
RAT               LRAARSRGAGTAWPSAIAGLVVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVAN 290
KANGAROO_RAT      VRAARSRGAGTAWPSAIAGLVVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVAN 289
ZEBRAFISH         IKTAESKGANTTWPSVIAGIVVALTAKVLRAFSPRFGKLVAEEARRKGDLRYMHSRIIAN 296
                  :::*.*:**.*:***.***:** ***:*******:**:**********:*******::**
                  .         .         .         .         .         .
HUMAN             SEEIAFYGGHEVELALLQRSYQDLASQINLILLERLWYVMLEQFLMKYVWSASGLLMVAV 349
GORILLA           SEEIAFYGGHEVELALLQRSYQDLASQINLILLERLWYVMLEQFLMKYVWSASGLLMVAV 349
CHIMPANZEE        SEEIAFYGGHEVELALLQRSYQDLASQINLILLERLWYVMLEQFLMKYVWSASGLLMVAV 349
MACAQUE           SEEIAFYGGHEVELALLQHSYQDLASQINLILLERLWYVMLEQFLMKYVWSASGLLMVAV 349
COW               SEEIAFYGGHEVELALLQHSYQDLASQINLILLERLWYVMLEQFLMKYVWSASGLLMVAV 354
DOG               SEEIAFYGGHEVELALLQHSYQDLASQINLILLERLWYIMLEQFLMKYVWSASGLLMVAV 349
MOUSE             SEEIAFYGGHEVELALLQHSYQDLASQINLILLERLWYVMLEQFLMKYVWSASGLLMVAV 349
RAT               SEEIAFYGGHEVELALLQHSYQDLASQINLILLERLWYVMLEQFLMKYVWSASGLLMVAV 350
KANGAROO_RAT      SEEIAFYGGHEVELALLQHSYQDLASQINLILLERLWYVMLEQFLMKYVWSASGLLMVAV 349
ZEBRAFISH         SEEIAFYGGHKIEMLQLQRSYNSLSRQINLILFKRLWYVMLEQFLMKYLWSASGLVMVAV 356
                  **********::*:  **:**:.*: ******::****:*********:******:****
                  .         .         .          .         .         .
HUMAN             PIITATGYSESDAEAVKKAALEKKEEE-LVSERTEAFTIARNLLTAAADAIERIMSSYKE 408
GORILLA           PIITATGYSESDAEAVKKAALEKKEEE-LVSERTEAFTIARNLLTAAADAIERIMSSYKE 408
CHIMPANZEE        PIITATGYSESDAEAVKKAALEKKEEE-LVSERTEAFTIARNLLTAAADAIERIMSSYKE 408
MACAQUE           PIITATGYSETDAEAVKKAALEKKEEE-LVSERTEAFTIARNLLTAAADAIERIMSSYKE 408
COW               PIITATGYSESDSETVKKAAQAMKEGE-LVSERTEAFTIARNLLTAAADAIERVMSSYKE 413
DOG               PIITATGYSESDSEAVKKAALEMREEE-LVSERTEAFTIARNLLTAAADAIERIMSSYKE 408
MOUSE             PIITATGYAESDSEAMKKAALEMKEEE-LVSERTEAFTIARNLLTAAADATERIMSSYKE 408
RAT               PIITATGYAESDSEAMKKAALEMKEEE-LVSERTEAFTIARNLLTAAADATERIMSSYKE 409
KANGAROO_RAT      PIITATGYSESDSETMKKAAFQKEEEEELVSERTEAFTIARNLLTAAADATERIMSSYKE 409
ZEBRAFISH         PIITATGYSKYDSEDVKQAALDMKEED-LVSERTQAFTTARSLLNAAADAVERIMVSYKE 415
                  ********:: *:* :*:**   .* : ******:*** **.**.***** **:* ****
                   .         .         .          .         .         .
HUMAN             VTELAGYTARVHEMFQVFEDVQRCHFKRPR-ELEDAQAGSGTIGRSGVRVEGPLKIRGQV 467
GORILLA           VTELAGYTARVHEMFQVFEDVQRCHFKRPR-ELEDAQAGSGTIGRSGVRVEGPLKIRGQV 467
CHIMPANZEE        VTELAGYTARVHEMFQVFEDVHRCHFKRPR-ELEDAQAGSGTIGRSGVRVEGPLKIRGQV 467
MACAQUE           VTELAGYTARVHEMFQVFEDVQRCHFKRPR-ELEDAQAGSGTIGRSGVRVEGPLKIRGQV 467
COW               VTELAGYTARVYEMFQVFEDVQQCRFKRPG-EPEDAHTGSGAIMRSGIRMEGPLQIRGQV 472
DOG               VTELAGYTARVHEMFQVFEDVQHCRFKRPG-ELEDTQAGPGAVARSGVHVEGPLQIRGQV 467
MOUSE             VTELAGYTARVYEMFQVFEDVKHCRFKRTG-DLEEAQAGPGVMVQSGVHVEGPLKIQGQV 467
RAT               VTELAGYTARVYEMFQVFEDVQHCRFKRTG-DLEEAQAGPGSMVHSGVHIEGPLKIQGQV 468
KANGAROO_RAT      VTELAGYTARVYEMFQVFEDVQHCRFKRPG-EPEDGHTGSVALVRSGVHIEGPLKIQGQV 468
ZEBRAFISH         VTELAGYTARVYEMFEVFEDVRDGVYRRSATEVKPEETGAPQNVTHGMRVEGPLQIRGQV 475
                  ***********:***:*****:   ::*.  : :  .:*.      *:::****:*:***
                    .         .         .         .         .         .
HUMAN             VDVEQGIICENIPIVTPSGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTY 527
GORILLA           VDVEQGIICENIPIVTPSGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTY 527
CHIMPANZEE        VDVEQGIICENIPIVTPSGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTY 527
MACAQUE           VDVEQGIICENIPIITPSGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTY 527
COW               VDVEQGIVCENIPIITPTGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTY 532
DOG               VDVEQGIICENIPIITPTGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTY 527
MOUSE             VDVEQGIICENIPIITPTGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTY 527
RAT               VDVEQGIICENIPIITPTGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTY 528
KANGAROO_RAT      VDVEQGIICENIPIITPTGDVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTY 528
ZEBRAFISH         IDVEQGIKCENLPIITPTGDVVVSSLNMQVDEGMHLLITGPNGCGKSSLFRILSGLWPVY 535
                  :****** ***:**:**:*:***:***::*:**********************.****.*
                    .         .         .         .         .         .
HUMAN             GGVLYKPPPQRMFYIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHH 587
GORILLA           GGVLYKPPPQRMFYIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHH 587
CHIMPANZEE        GGVLYKPPPQRMFYIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHH 587
MACAQUE           GGVLYKPPPQRMFYIPQRPYMSVGSLRDQVIYPDSVADMRRKGYSEQDLEAILDIVHLHH 587
COW               GGVLYKPPPQRMFYIPQRPYMSVGSLRDQVIYPDSVEDMRRKGYSEEHLEGILDIVHLNH 592
DOG               GGVLYKPPPQRMFYIPQRPYMSVGSLRDQVIYPDSVEDMRRKGYSEQHLEAILDIVHLNH 587
MOUSE             SGVLYKPPPQRMFYIPQRPYMSVGSLRDQVIYPDSAEDMRRKGCSEQQLEAILGIVHLRH 587
RAT               SGVLYKPPPQRMFYIPQRPYMSVGSLRDQVIYPDSAEDMRRKGCSEQQLEAILGIVHLRH 588
KANGAROO_RAT      GGVLYKPPPQRMFYIPQRPYMSVGSLRDQVIYPDSVEDMRRKGYSEQQLEAILDIVHLHH 588
ZEBRAFISH         SGVLYKPSPDHMFYIPQRPYMSVGTLRDQVIYPHSVQEMQEKGITDRQLEEILQTVSLRY 595
                  .******.*::*************:********.*. :*:.** ::..** **  * *.:
                    .         .         .         .         .         .
HUMAN             ILQREGGWEAMCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAA 647
GORILLA           ILQREGGWEAMCDWKDVLPGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAA 647
CHIMPANZEE        ILQREGGWEAVCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAA 647
MACAQUE           ILQREGGWEAMCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAA 647
COW               ILQREGGWEAVCDWKDVLSGGEKQRVGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAA 652
DOG               ILQREGGWEAVCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAA 647
MOUSE             ILQREGGWEAVCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAA 647
RAT               ILQREGGWEAVCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAA 648
KANGAROO_RAT      ILQREGGWEAVCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAA 648
ZEBRAFISH         ILEREGGWDAVSDWKDVLSGGEKQRMGMARMFYHKPQYALLDECTSAVSIDVEGKIFEAA 655
                  **:*****:*:.******.******:********:*:********************:**
                    .         .         .         .         .         .
HUMAN             KDAGIALLSITHRPSLWKYHTHLLQFDGEGGWKFEKLDSAARLSLTEEKQRLEQQLAGIP 707
GORILLA           KDAGIALLSITHRPSLWKYHTHLLQFDGEGGWKFEKLDSAARLSLTEEKQRLEQQLAGIP 707
CHIMPANZEE        KDAGIALLSITHRPSLWKYHTHLLQFDGEGGWKFEKLDSAARLSLTEEKQRLEQQLAGIP 707
MACAQUE           KDAGIALLSITHRPSLWKYHTHLLQFDGEGGWKFEKLDSAARLSLTEEKQRLEQQLAGIP 707
COW               KDAGIALLSITHRPSLWKYHTHLLQFDGEGGWKFEKLDSAARLSLTEEKQRLEQQLAGIP 712
DOG               KDAGIALLSITHRPSLWKYHTHLLQFDGEGGWKFEKLDSAARLSLTEEKQRLEQQLAGIP 707
MOUSE             KDAGIALLSITHRPSLWKYHTHLLQFDGEGGWKFEKLDSAARLSLTEEKQRLEQQLAGIP 707
RAT               KDAGISLLSITHRPSLWKYHTHLLQFDGEGGWKFEKLDSAARLSLTEEKQRLEQQLAGIP 708
KANGAROO_RAT      KDAGIALLSITHRPSLWKYHTHLLQFDGEGGWKFEKLDSATRLSLTEEKQRLEQQLAGIP 708
ZEBRAFISH         KDAGISLLSITHRPSLWKYHSHLLQFDGEGGWRFEKLDASTRISLQDEKIRLETQLSGIP 715
                  *****:**************:***********:*****:::*:** :** *** **:***
                    .         .         .         .
HUMAN             KMQRRLQELCQILGEAVAPAHVPAPSPQGPGGLQGAST 745
GORILLA           KMQRRLQELCQILGEAVAPAHVPAPSPQGPGGLQGAST 745
CHIMPANZEE        KMQRRLQELCQILGEAVAPAHVPAPSPQGPGGLQGAST 745
MACAQUE           KMQRRLQELCQILGEAMAPAQVPAPSSQDPGGLQGAST 745
COW               KMQRRLQELCQILG-------------QGPGANQGTAT 737
DOG               KMQRRLQELCQILG-------------QGSGVLQGAVP 732
MOUSE             KMQGRLQELRQILGEAAAPVQPLVP-----GVPT---- 736
RAT               KMQGRLQELRQILGEAAAPVQPLVP-----GIPT---- 737
KANGAROO_RAT      KIQGRLQELRQILGEAVAPEKPSAASLPGSGLPT---- 742
ZEBRAFISH         KMQQRLTELCRILGEDSSLP------------------ 735
                  *:* ** ** :***

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