Región codificante de ABCD1

November 2nd, 2010 |

La región codificante del ADNc de ABCD1

La secuencia original del ADNc del gen involucrado en ALD- X (ABCD1) que fue registrado por Mosser et al. en 1993 contenía un error de la secuencia de nucleótidos en la posición 368. El aminoácido en la posición 123 debe ser una valina en lugar de una alanina. Esta página contiene la información corregida del “marco de lectura abierto” y la secuencia del ARNm del gen para ALD -X (ABCD1).

Gen de ALD -X (ABCD1): marco abierto de lectura

ATG CCG GTG CTC TCC AGG CCC CGG CCC TGG CGG GGG AAC ACG CTG AAG CGC ACG GCC GTG 60
Met Pro Val Leu Ser Arg Pro Arg Pro Trp Arg Gly Asn Thr Leu Lys Arg Thr Ala Val 20

CTC CTG GCC CTC GCG GCC TAT GGA GCC CAC AAA GTC TAC CCC TTG GTG CGC CAG TGC CTG 120
Leu Leu Ala Leu Ala Ala Tyr Gly Ala His Lys Val Tyr Pro Leu Val Arg Gln Cys Leu 40

GCC CCG GCC AGG GGT CTT CAG GCG CCC GCC GGG GAG CCC ACG CAG GAG GCC TCC GGG GTC 180
Ala Pro Ala Arg Gly Leu Gln Ala Pro Ala Gly Glu Pro Thr Gln Glu Ala Ser Gly Val 60

GCG GCG GCC AAA GCT GGC ATG AAC CGG GTA TTC CTG CAG CGG CTC CTG TGG CTC CTG CGG 240
Ala Ala Ala Lys Ala Gly Met Asn Arg Val Phe Leu Gln Arg Leu Leu Trp Leu Leu Arg 80

CTG CTG TTC CCC CGG GTC CTG TGC CGG GAG ACG GGG CTG CTG GCC CTG CAC TCG GCC GCC 300
Leu Leu Phe Pro Arg Val Leu Cys Arg Glu Thr Gly Leu Leu Ala Leu His Ser Ala Ala 100

TTG GTG AGC CGC ACC TTC CTG TCG GTG TAT GTG GCC CGC CTG GAC GGA AGG CTG GCC CGC 360
Leu Val Ser Arg Thr Phe Leu Ser Val Tyr Val Ala Arg Leu Asp Gly Arg Leu Ala Arg 120

TGC ATC GtC CGC AAG GAC CCG CGG GCT TTT GGC TGG CAG CTG CTG CAG TGG CTC CTC ATC 420
Cys Ile Val Arg Lys Asp Pro Arg Ala Phe Gly Trp Gln Leu Leu Gln Trp Leu Leu Ile 140

GCC CTC CCT GCT ACC TTC GTC AAC AGT GCC ATC CGT TAC CTG GAG GGC CAA CTG GCC CTG 480
Ala Leu Pro Ala Thr Phe Val Asn Ser Ala Ile Arg Tyr Leu Glu Gly Gln Leu Ala Leu 160

TCG TTC CGC AGC CGT CTG GTG GCC CAC GCC TAC CGC CTC TAC TTC TCC CAG CAG ACC TAC 540
Ser Phe Arg Ser Arg Leu Val Ala His Ala Tyr Arg Leu Tyr Phe Ser Gln Gln Thr Tyr 180

TAC CGG GTC AGC AAC ATG GAC GGG CGG CTT CGC AAC CCT GAC CAG TCT CTG ACG GAG GAC 600
Tyr Arg Val Ser Asn Met Asp Gly Arg Leu Arg Asn Pro Asp Gln Ser Leu Thr Glu Asp 200

GTG GTG GCC TTT GCG GCC TCT GTG GCC CAC CTC TAC TCC AAC CTG ACC AAG CCA CTC CTG 660
Val Val Ala Phe Ala Ala Ser Val Ala His Leu Tyr Ser Asn Leu Thr Lys Pro Leu Leu 220

GAC GTG GCT GTG ACT TCC TAC ACC CTG CTT CGG GCG GCC CGC TCC CGT GGA GCC GGC ACA 720
Asp Val Ala Val Thr Ser Tyr Thr Leu Leu Arg Ala Ala Arg Ser Arg Gly Ala Gly Thr 240

GCC TGG CCC TCG GCC ATC GCC GGC CTC GTG GTG TTC CTC ACG GCC AAC GTG CTG CGG GCC 780
Ala Trp Pro Ser Ala Ile Ala Gly Leu Val Val Phe Leu Thr Ala Asn Val Leu Arg Ala 260

TTC TCG CCC AAG TTC GGG GAG CTG GTG GCA GAG GAG GCG CGG CGG AAG GGG GAG CTG CGC 840
Phe Ser Pro Lys Phe Gly Glu Leu Val Ala Glu Glu Ala Arg Arg Lys Gly Glu Leu Arg 280

TAC ATG CAC TCG CGT GTG GTG GCC AAC TCG GAG GAG ATC GCC TTC TAT GGG GGC CAT GAG 900
Tyr Met His Ser Arg Val Val Ala Asn Ser Glu Glu Ile Ala Phe Tyr Gly Gly His Glu 300

GTG GAG CTG GCC CTG CTA CAG CGC TCC TAC CAG GAC CTG GCC TCG CAG ATC AAC CTC ATC 960
Val Glu Leu Ala Leu Leu Gln Arg Ser Tyr Gln Asp Leu Ala Ser Gln Ile Asn Leu Ile 320

CTT CTG GAA CGC CTG TGG TAT GTT ATG CTG GAG CAG TTC CTC ATG AAG TAT GTG TGG AGC 1020
Leu Leu Glu Arg Leu Trp Tyr Val Met Leu Glu Gln Phe Leu Met Lys Tyr Val Trp Ser 340

GCC TCG GGC CTG CTC ATG GTG GCT GTC CCC ATC ATC ACT GCC ACT GGC TAC TCA GAG TCA 1080
Ala Ser Gly Leu Leu Met Val Ala Val Pro Ile Ile Thr Ala Thr Gly Tyr Ser Glu Ser 360

GAT GCA GAG GCC GTG AAG AAG GCA GCC TTG GAA AAG AAG GAG GAG GAG CTG GTG AGC GAG 1140
Asp Ala Glu Ala Val Lys Lys Ala Ala Leu Glu Lys Lys Glu Glu Glu Leu Val Ser Glu 380

CGC ACA GAA GCC TTC ACT ATT GCC CGC AAC CTC CTG ACA GCG GCT GCA GAT GCC ATT GAG 1200
Arg Thr Glu Ala Phe Thr Ile Ala Arg Asn Leu Leu Thr Ala Ala Ala Asp Ala Ile Glu 400

CGG ATC ATG TCG TCG TAC AAG GAG GTG ACG GAG CTG GCT GGC TAC ACA GCC CGG GTG CAC 1260
Arg Ile Met Ser Ser Tyr Lys Glu Val Thr Glu Leu Ala Gly Tyr Thr Ala Arg Val His 420

GAG ATG TTC CAG GTA TTT GAA GAT GTT CAG CGC TGT CAC TTC AAG AGG CCC AGG GAG CTA 1320
Glu Met Phe Gln Val Phe Glu Asp Val Gln Arg Cys His Phe Lys Arg Pro Arg Glu Leu 440

GAG GAC GCT CAG GCG GGG TCT GGG ACC ATA GGC CGG TCT GGT GTC CGT GTG GAG GGC CCC 1380
Glu Asp Ala Gln Ala Gly Ser Gly Thr Ile Gly Arg Ser Gly Val Arg Val Glu Gly Pro 460

CTG AAG ATC CGA GGC CAG GTG GTG GAT GTG GAA CAG GGG ATC ATC TGC GAG AAC ATC CCC 1440
Leu Lys Ile Arg Gly Gln Val Val Asp Val Glu Gln Gly Ile Ile Cys Glu Asn Ile Pro 480

ATC GTC ACG CCC TCA GGA GAG GTG GTG GTG GCC AGC CTC AAC ATC AGG GTG GAG GAA GGC 1500
Ile Val Thr Pro Ser Gly Glu Val Val Val Ala Ser Leu Asn Ile Arg Val Glu Glu Gly 500

ATG CAT CTG CTC ATC ACA GGC CCC AAT GGC TGC GGC AAG AGC TCC CTG TTC CGG ATC CTG 1560
Met His Leu Leu Ile Thr Gly Pro Asn Gly Cys Gly Lys Ser Ser Leu Phe Arg Ile Leu 520

GGT GGG CTC TGG CCC ACG TAC GGT GGT GTG CTC TAC AAG CCC CCA CCC CAG CGC ATG TTC 1620
Gly Gly Leu Trp Pro Thr Tyr Gly Gly Val Leu Tyr Lys Pro Pro Pro Gln Arg Met Phe 540

TAC ATC CCG CAG AGG CCC TAC ATG TCT GTG GGC TCC CTG CGT GAC CAG GTG ATC TAC CCG 1680
Tyr Ile Pro Gln Arg Pro Tyr Met Ser Val Gly Ser Leu Arg Asp Gln Val Ile Tyr Pro 560

GAC TCA GTG GAG GAC ATG CAA AGG AAG GGC TAC TCG GAG CAG GAC CTG GAA GCC ATC CTG 1740
Asp Ser Val Glu Asp Met Gln Arg Lys Gly Tyr Ser Glu Gln Asp Leu Glu Ala Ile Leu 580

GAC GTC GTG CAC CTG CAC CAC ATC CTG CAG CGG GAG GGA GGT TGG GAG GCT ATG TGT GAC 1800
Asp Val Val His Leu His His Ile Leu Gln Arg Glu Gly Gly Trp Glu Ala Met Cys Asp 600

TGG AAG GAC GTC CTG TCG GGT GGC GAG AAG CAG AGA ATC GGC ATG GCC CGC ATG TTC TAC 1860
Trp Lys Asp Val Leu Ser Gly Gly Glu Lys Gln Arg Ile Gly Met Ala Arg Met Phe Tyr 620

CAC AGG CCC AAG TAC GCC CTC CTG GAT GAA TGC ACC AGC GCC GTG AGC ATC GAC GTG GAA 1920
His Arg Pro Lys Tyr Ala Leu Leu Asp Glu Cys Thr Ser Ala Val Ser Ile Asp Val Glu 640

GGC AAG ATC TTC CAG GCG GCC AAG GAC GCG GGC ATT GCC CTG CTC TCC ATC ACC CAC CGG 1980
Gly Lys Ile Phe Gln Ala Ala Lys Asp Ala Gly Ile Ala Leu Leu Ser Ile Thr His Arg 660

CCC TCC CTG TGG AAA TAC CAC ACA CAC TTG CTA CAG TTC GAT GGG GAG GGC GGC TGG AAG 2040
Pro Ser Leu Trp Lys Tyr His Thr His Leu Leu Gln Phe Asp Gly Glu Gly Gly Trp Lys 680

TTC GAG AAG CTG GAC TCA GCT GCC CGC CTG AGC CTG ACG GAG GAG AAG CAG CGG CTG GAG 2100
Phe Glu Lys Leu Asp Ser Ala Ala Arg Leu Ser Leu Thr Glu Glu Lys Gln Arg Leu Glu 700

CAG CAG CTG GCG GGC ATT CCC AAG ATG CAG CGG CGC CTC CAG GAG CTC TGC CAG ATC CTG 2160
Gln Gln Leu Ala Gly Ile Pro Lys Met Gln Arg Arg Leu Gln Glu Leu Cys Gln Ile Leu 720

GGC GAG GCC GTG GCC CCA GCG CAT GTG CCG GCA CCT AGC CCG CAA GGC CCT GGT GGC CTC 2220
Gly Glu Ala Val Ala Pro Ala His Val Pro Ala Pro Ser Pro Gln Gly Pro Gly Gly Leu 740

CAG GGT GCC TCC ACC TGA 2238
Gln Gly Ala Ser Thr *** 745